Endocrine Abstracts

Objective: To investigate the blood pressure control in type 2 diabetic patients with overweight or obesity in Guangdong Province.Methods: From August 2011 to March 2012, The 2 diabetic patients with overweight or obesity was recruited from 67 hospitals in 20 cities of Guangdong Province, and received a standard questionnaire. The conditions of Demographic data, clinical examinations, the most recent laboratory assessment, and drug therapy were recorded....

Background: Patients with neuroendocrine tumors (NETs) have a 5-year survival rate of 30-60%. Surgery, and newly approved ‘tar-geted radionuclide therapy (TRT)’ with [177Lu]DOTATATE, are the only curative options for patients with NETs. TRT is limited to pa--tients that have high levels of somatostatin receptor subtype 2 (SSTR2) and can im-prove the survival of patients with low-grade tumors, but has little effect on high-grade NETs that express low SSTR2 ...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers. However, regarding metastatic poorly differentiated or anaplastic thyroid cancers, there have been no available effective treatment modalities. The genomic instability, such as chromosome aneupolidy, represents a hallmark of s...

Background: Cancer cells utilize both oxidative phosphorylation (OXPHOS) and glycolysis to generate energy. Switching between OXPHOS and glycolysis can promote tumor progression. The mechanisms governing oncogenic metabolic flexibility are largely unknown, but recent data has suggested that Notch1 dysregulation in cancer cells can contribute to altered metabolic phenotypes. We hypothesized that Notch1 signaling supports metabolic flexibility in pancreatic neuroendocrine tumor ...

Background: Following IHC of CALR, H-scoring was performed by a pathologist. H-scoring was validated by MIF of the same tissue, wherein random-forest machine learning (ML) classifiers were employed to classify cells. ML classifiers were trained to distinguish between pNET cells and tumor stroma using approximately 30% of cells for the respective cell population of interest in each TMA core. Pearson’s correlations were used to evaluate the relationship between H-scoring an...

Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones such as pro-opiomelanocortin, proinsulin, proglucagon into biologically active peptides. Inherited genomic mutations of PCSK1 present with malabsorptive diarrhoea, hyperinsulinemic hypoglycaemia, central adrenal and thyroid defects and severe obesity. Somatic mutations of insulinomas are associated with genetic defects interfering with insulin secreti...

Objectives: Overweight and obesity currently burden our public health, and especially with the aging process in the world, the incidence of obesity is significantly higher in women than that in men partly. Recent studies reported that hypothalamic kisspeptin neurons, with obvious changes of number and structure in female during life, play a crucial role in the regulation of central energy homeostasis. But the precise mechanism remains an enigma.Methods: ...

Background: Bilateral cataracts are rarely the initial symptom of diabetes mellitus (DM). Patients with DM who developed cataracts usually have DM for many years. The prevalence of early cataracts in paediatric DM ranges between 0.7 and 3.4%. We report a case of DM diagnosis following onset of blindness due to new bilateral cataracts.Case description: 13-year-old Caucasian girl presented with rapidly declining vision for 2 months. She was blind 2 weeks p...

Background: There are known outcome disparities between Black and White patients with pancreatic neuroendocrine tumors (pNETs). Recently, Black patients were shown to have higher rates of lymph node metastasis in smaller tumors than White patients, indicating possible differences in tumor biology. Numerous prognostic gene expression differences between racial groups have been reported in other cancers, but no such analysis has been conducted in pNETs. This study evaluated pNET...

Background: Since the FDA-approval of Lu177-DOTATATE and I131-MIBG radiopharmaceutical therapies in 2018, there is emerging real-world experience with their use. Only a few institutions in the US have both therapies available. Here, we describe our experience with these agents for patients with pheochromocytoma and paraganglioma (PPGL).Methods: This is a retrospective evaluation of all patients with progressive, metastatic, PPGL referred for radiopharmac...